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Further Information
Bioactivity:
MAIT-203 acetate is a cyclopentylglycine-derived peptidomimetic that effectively inhibits the interaction between adenomatous polyposis coli (APC) and Asef (RhoGEF4), while not affecting the APC-Sam68 or APC-striatin interactions. It binds to APC-ARM with a Ki of 0.015 uM and a Kd of 0.036 uM, significantly impeding the migration and invasion of colorectal cancer cells.