TargetMol

Breast cancer targeting peptide 18?4

Product Code:
 
TAR-TP3074
Product Group:
 
Peptides
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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This product comes from: Austria.
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Further Information

Bioactivity:
Breastcancertargeting peptide 18?4 is a keratin 1 (KRT1) receptor-targeting peptide with a dissociation constant (Kd) of 0.98 uM. Its amino acid sequence is WxEAAYQrFL, and it is an analogue of the P160 peptide. When covalently bonded with the anticancer peptide MccJ25, it significantly enhances MccJ25 uptake in breast cancer cells and boosts its anticancer efficacy. The IC50 values for this covalent compound are 14.2, 20, and 25 uM against MCF-7, MDA-MB-435, and MDA-MB-435-MDR, respectively.
CAS Number:
1332850-08-4
Formula:
C63H89N15O15
Molwt:
1296.47
Pathway:
Cytoskeletal Signaling
SMILES:
C([C@@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@H](C(N[C@@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)=O)C)=O)C)=O)CCC(O)=O)=O)CCCC)=O)N)C=3C=4C(NC3)=CC=CC4
Target:
Microtubule Associated

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