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Further Information
Bioactivity:
Corza6 is a potent and selective peptide inhibitor of the human voltage-gated proton channel (hHv1). It binds to the external voltage sensor domain (VSD) loop in hHv1 at a resting membrane potential (RMP) of natural hyperpolarization in mammalian cells with a Kd of approximately 1 nM. Corza6 facilitates sperm capacitation and permits sustained production of reactive oxygen species (ROS) in leukocytes (WBC).
