TargetMol

Ac-DMLD-CMK

Product Code:
 
TAR-TP3236
Product Group:
 
Peptides
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-TP3236-10mg10 mgEnquire
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TAR-TP3236-50mg50 mgEnquire
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This product comes from: Austria.
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Further Information

Bioactivity:
Ac-DMLD-CMK is a peptide designed to target the caspase3-Gsdme signaling pathway in mice. It specifically inhibits the activation of caspase 3 and Gsdme, preventing the cleavage of Gsdme by caspase 3, which reduces pyroptosis. This process helps alleviate damage to renal tubular epithelial cells and decrease the secretion of inflammatory cytokines. Ac-DMLD-CMK can lower serum creatinine and blood urea nitrogen levels in mice induced by Cisplatin, thereby mitigating the progression of renal dysfunction. It holds potential for research into chemotherapy-induced nephrotoxicity.
CAS Number:
2588354-33-8
Formula:
C22H35ClN4O9S
Molwt:
567.053
Pathway:
Immunology/Inflammation|Proteases/Proteasome|Apoptosis
SMILES:
[C@H](C(N[C@H](C(CCl)=O)CC(O)=O)=O)(NC([C@@H](NC([C@H](CC(O)=O)NC(C)=O)=O)CCSC)=O)CC(C)C
Target:
Caspase|Pyroptosis

Documents