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Further Information
Bioactivity:
Cyclo CRLLIF serves as a dual inhibitor of hypoxia-inducible factors HIF1 and HIF2, disrupting the interaction between HIF1-α and HIF2-α with HIF1-β. It exhibits dissociation constants (KD) of 14.5 uM for HIF1-α and 10.2 uM for HIF2-α within the PAS-B domains.
