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Further Information
Bioactivity:
TAT-AKAP79 326-336 is a cell-penetrating peptide that mimics a specific region (amino acid sequence 326-336) of the AKAP79 protein, which interacts with the TRPV1 ion channel. It can inhibit the sensitization of TRPV1, thus reducing the hyperreaction of the TRPV1 channel to stimuli caused by the activation of cellular kinases by inflammatory mediators, such as protein kinase A (PKA) and protein kinase C (PKC). TAT-AKAP79 326-336 is valuable for researching mechanisms of nociception and inflammatory hyperalgesia.
