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Further Information
Bioactivity:
Tat-beclin 1scrambled is the disordered segment and control of Tat-beclin 1, derived from a region of the autophagy protein beclin 1. Beclin 1 induces autophagy by interacting with HIV-1Nef and the autophagy inhibitory factor GAPR-1 (GLIPR2). Tat-beclin 1 decreases both the accumulation of polyglutamine-expanded protein aggregates and the replication of several pathogens, such as HIV. Additionally, Tat-beclin 1 reduces mortality rates in mice infected with chikungunya or West Nile virus.
