TargetMol

NH2-PEG1-Val-Cit-PAB-OH

Product Code:
 
TAR-TYD-01967
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-TYD-01967-10mg10 mgEnquire
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TAR-TYD-01967-50mg50 mgEnquire
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This product comes from: Austria.
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Further Information

Bioactivity:
NH2-PEG1-Val-Cit-PAB-OH is a cleavable ADC linker with a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzyl alcohol on the PAB group facilitates conjugation reactions with groups like PNP for binding drug payloads. The primary amine is versatile in participating in reactions such as coupling with carboxylic acids, reductive amination with ketones or aldehydes, and more specialized applications like SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by intracellular proteases, allowing efficient payload delivery through an elimination mechanism within the PAB structure.
CAS Number:
2055024-63-8
Formula:
C23H38N6O6
Molwt:
494.584
Pathway:
Antibody-drug Conjugate/ADC Related
SMILES:
[C@H](C(NC1=CC=C(CO)C=C1)=O)(NC([C@@H](NC(CCOCCN)=O)[C@@H](C)C)=O)CCCNC(N)=O
Target:
ADC Linker

Documents