TargetMol

Fmoc-PEG4-Val-Cit-PAB-OH

Product Code:
 
TAR-TYD-01988
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-TYD-01988-10mg10 mgEnquire
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TAR-TYD-01988-50mg50 mgEnquire
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This product comes from: Austria.
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Further Information

Bioactivity:
Fmoc-PEG4-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker that incorporates a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on PAB can be used to attach reactive groups (such as PNP) for drug payload conjugation. The Fmoc protecting group can be removed with piperidine to expose a primary amine, facilitating amide bond formation. Val-Cit-PAB is cleaved by cellular proteases to efficiently release the payload inside cells.
CAS Number:
2055024-58-1
Formula:
C44H60N6O11
Molwt:
848.981
Pathway:
Antibody-drug Conjugate/ADC Related
SMILES:
C(OC(NCCOCCOCCOCCOCCC(N[C@H](C(N[C@H](C(NC1=CC=C(CO)C=C1)=O)CCCNC(N)=O)=O)[C@H](C)C)=O)=O)C2C=3C(C=4C2=CC=CC4)=CC=CC3
Target:
ADC Linker

Documents