TargetMol

(S, R, S)-MI-1061

Product Code:
 
TAR-TYD-02774
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-TYD-02774-10mg10 mgEnquire
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TAR-TYD-02774-50mg50 mgEnquire
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This product comes from: Austria.
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Further Information

Bioactivity:
(S,R,S)-MI-1061 is an isomer of MI-1061. It serves as a precursor for synthesizing Antibody-Drug Conjugates (ADCs). MI-1061 acts as a potent, orally bioavailable, and chemically stable inhibitor of MDM2 (MDM2-p53 interaction) with IC50=4.4 nM and Ki=0.16 nM. This compound activates p53 and induces apoptosis in murine SJSA-1 xenograft tissues, exhibiting antitumor properties.
CAS Number:
1410738-90-7
Formula:
C30H26Cl2FN3O4
Molwt:
582.45
Pathway:
Antibody-drug Conjugate/ADC Related|Apoptosis
SMILES:
O=C1[C@]2(C3(N[C@H](C(NC4=CC=C(C(O)=O)C=C4)=O)[C@H]2C5=C(F)C(Cl)=CC=C5)CCCCC3)C=6C(N1)=CC(Cl)=CC6
Target:
Drug-Linker Conjugates for ADC|MDM-2/p53

Documents