TargetMol

(Rac)-Vepdegestrant

Product Code:
 
TAR-TYD-02806
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-TYD-02806-10mg10 mgEnquire
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TAR-TYD-02806-50mg50 mgEnquire
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This product comes from: Austria.
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Further Information

Bioactivity:
(Rac)-Vepdegestrant is an isomer of Vepdegestrant. Vepdegestrant ((Rac)-ARV-471) is an orally active estrogen receptor PROTAC degrader used against breast cancer. It is a heterobifunctional molecule that facilitates the interaction between estrogen receptor α and the intracellular E3 ligase complex. Vepdegestrant induces ubiquitination and subsequent degradation of the estrogen receptor via the proteasome, effectively degrading ER in ER-positive breast cancer cell lines with a DC50 value of approximately 2 nM.
CAS Number:
2229711-08-2
Formula:
C45H49N5O4
Molwt:
723.9
Pathway:
Endocrinology/Hormones|PROTAC
SMILES:
OC=1C=C2C([C@H]([C@H](CC2)C3=CC=CC=C3)C4=CC=C(C=C4)N5CCC(CN6CCN(CC6)C=7C=C8C(=CC7)C(=O)N(C8)C9C(=O)NC(=O)CC9)CC5)=CC1
Target:
Estrogen Receptor/ERR|PROTACs

Documents