Skp1-Skp2-Complex (human) (rec.) (His)
Product Code:
SBB-SC0118
SBB-SC0118
Regulatory Status:
RUO
RUO
Target Species:
Human
Human
Shipping:
Dry Ice
Dry Ice
Storage:
Short term: -80°C. Long term: -80°C
Short term: -80°C. Long term: -80°C
No additional charges, what you see is what you pay! *
| Code | Size | Price |
|---|
| SBB-SC0118-C025 | 25 ug | £376.00 |
Quantity:
| SBB-SC0118-C050 | 50 ug | £607.00 |
Quantity:
Prices exclude any Taxes / VAT
Stay in control of your spending. These prices have no additional charges to UK mainland customers, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: Switzerland.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
- Further Information
- Documents
- Show All
Further Information
Alternate Names/Synonyms:
S-phase Kinase-associated Protein 1 / S-phase Kinase-associated Protein 2
Concentration:
Lot dependent.
EClass:
32160000
Form:
liquid
Formulation:
Liquid. In 50mM HEPES pH 7.5, 150mM NaCl, 1mM TCEP.
Handling Advice:
Aliquot to avoid freeze/thaw cycles.
Long Description:
Recombinant Protein. Recombinant human Skp1 (1-163) and Skp2 (1-424) heterodimer. N-terminal His-tag on Skp2. Produced in Sf9 cells. Liquid. In 50mM HEPES pH 7.5, 150mM NaCl, 1mM TCEP. SKP1 (S-phase kinase-associated protein 1) is an essential component of SCF (SKP1-CUL1-F-box protein) E3 Ubiquitin ligases that mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SKP1 is the adapter protein that links Cullin-1 to various F-box proteins (such as SKP2) that serve as the substrate recognition components of SCF ligases. SKP2 targets include proteins involved in cell cycle progression and signal transduction. SKP2 recognizes phosphorylated CDKN1B/ p27Kip and is involved in G1-S cell cycle transition in a CKS1-dependent manner. The Skp1/Skp2 comlex is associated with Cullin-1 (CUL1) a core component of multiple SCF (SKP1-CUL1-F-box) E3 Ubiquitin ligase complexes mediating the ubiquitination of proteins. This complex consists of an N-terminal 6x-His tagged Skp2 and an untagged Skp1. The complex has been expressed and purified from insect cells Sf9.
NCBI, Uniprot Number:
P63208: SKP1 / Q13309: SKP2
Package Type:
Plastic Vial
Product Description:
SKP1 (S-phase kinase-associated protein 1) is an essential component of SCF (SKP1-CUL1-F-box protein) E3 Ubiquitin ligases that mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SKP1 is the adapter protein that links Cullin-1 to various F-box proteins (such as SKP2) that serve as the substrate recognition components of SCF ligases. SKP2 targets include proteins involved in cell cycle progression and signal transduction. SKP2 recognizes phosphorylated CDKN1B/ p27Kip and is involved in G1-S cell cycle transition in a CKS1-dependent manner. The Skp1/Skp2 comlex is associated with Cullin-1 (CUL1) a core component of multiple SCF (SKP1-CUL1-F-box) E3 Ubiquitin ligase complexes mediating the ubiquitination of proteins. This complex consists of an N-terminal 6x-His tagged Skp2 and an untagged Skp1. The complex has been expressed and purified from insect cells Sf9.
Purity:
>95% (SDS-PAGE)
Sequence:
Recombinant human Skp1 (1-163) and Skp2 (1-424) heterodimer. N-terminal His-tag on Skp2.
Source / Host:
Sf9 cells
TAGs:
His
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 1 year after receipt when stored at -80°C.