RF-Absorbent
Product Code:
LEI-Z200QED
LEI-Z200QED
Product Group:
Assay Supporting Tools and Kit Components
Assay Supporting Tools and Kit Components
Supplier:
Leinco Technologies
Leinco Technologies
Regulatory Status:
RUO
RUO
Application:
Immunoassay (IA)
Immunoassay (IA)
Storage:
2-8°C
2-8°C
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This product comes from: United States.
Typical lead time: 14-21 working days.
Contact us for more accurate information.
Typical lead time: 14-21 working days.
Contact us for more accurate information.
- Further Information
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Further Information
Description:
SERION Rheumatoid Factor (Rf)-Absorbent for IgM-Antibody-Detection - Anti- human- IgG for the removal of IgM- rheumatoid factors from serum- and plasmaprobes or cerebrospinal fluid (CSF) which are to be prepared for the detection of specific IgM-antibodies in indirect Immunoassays.
Principle of Method
Rheumatoid factors are autoantibodies (anti-IgG) mainly of the IgM-class. They can be detected in the serum of approx. 5 % of healthy individuals. IgM-rheumatoid factors preferably bind to IgG-immune-complexes; therefore, false positive results may appear in the pathogen-specific IgM-detection. Furthermore, the possibility exists, that weakbinding pathogen-specific IgM antibodies are displaced by stronger-binding IgG antibodies. In this case, IgM-detection can bring about false negative results. In IgAdetection possibly occuring competition with IgG-antibodies can also be prevented by eliminating IgG with Rf-absorbent. The SERION Rf-absorbent precipitates up to 15 mg IgG/ml (undiluted serum). The IgMrheumatoid factor binds to the precipitate. Consequently, the IgG-antibodies as well as the IgM-rheumatoid factors are not reactive in the immunoassay. The use of SERION rheumatoid factor-absorbent can minimize false positive as well as false negative results.
For Research Use Only
Principle of Method
Rheumatoid factors are autoantibodies (anti-IgG) mainly of the IgM-class. They can be detected in the serum of approx. 5 % of healthy individuals. IgM-rheumatoid factors preferably bind to IgG-immune-complexes; therefore, false positive results may appear in the pathogen-specific IgM-detection. Furthermore, the possibility exists, that weakbinding pathogen-specific IgM antibodies are displaced by stronger-binding IgG antibodies. In this case, IgM-detection can bring about false negative results. In IgAdetection possibly occuring competition with IgG-antibodies can also be prevented by eliminating IgG with Rf-absorbent. The SERION Rf-absorbent precipitates up to 15 mg IgG/ml (undiluted serum). The IgMrheumatoid factor binds to the precipitate. Consequently, the IgG-antibodies as well as the IgM-rheumatoid factors are not reactive in the immunoassay. The use of SERION rheumatoid factor-absorbent can minimize false positive as well as false negative results.
For Research Use Only