Mouse IL-17C (Interleukin 17C) ELISA Kit
Product Code:
E-EL-M3131
E-EL-M3131
Regulatory Status:
RUO
RUO
Target Species:
Mouse
Mouse
Application:
Enzyme-Linked Immunosorbent Assay (ELISA)
Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
Ice bag
Ice bag
Storage:
2-8°C
2-8°C
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This product comes from: China.
Typical lead time: 14-21 working days.
Contact us for more accurate information.
Typical lead time: 14-21 working days.
Contact us for more accurate information.
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Further Information
Assay Time:
3 h 30 min
Background:
IL-17C(Interleukin 17C) is a pro-inflammatory cytokine that plays a crucial role in epithelial innate immunity, especially against intestinal bacterial pathogens, acting in an autocrine manner. It stimulates the production of antibacterial peptides and pro-inflammatory molecules for host defense via activating the NFKB and MAPK signaling pathways. It acts synergistically with IL22, TNF and IL1B to induce antibacterial peptides. It may exert a protective effect by maintaining epithelial homeostasis after inflammatory challenges, such as intestinal inflammation in a dextran sulfate sodium-induced colitis model. It can also promote an inflammatory phenotype, e.g., in psoriatic skin. Enhanced IL17C/IL17RE signaling may increase susceptibility to autoimmune diseases like autoimmune encephalitis.
Cross Reactivity:
This kit recognizes Mouse IL-17C in samples.No significant cross-reactivity or interference between and analogues was observed
Detection Range:
15.63-1000 pg/mL
Detection Type:
Colorimetric method, ELISA, Sandwich
Expiry date:
12 months
GeneID:
234836
Precision:
Both intra-CV and inter-CV are < 10%.
Recovery rate:
80%-120%
Sensitivity:
9.38 pg/mL
Target Synonym:
Interleukin-17C, Il-17c, Cytokine CX2
Test Principle:
This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse IL-17C. Standards or samples are added to the micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for Mouse IL-17C and Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse IL-17C, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm ? 7 nm. The OD value is proportional to the concentration of Mouse IL-17C. You can calculate the concentration of Mouse IL-17C in the samples by comparing the OD of the samples to the standard curve.
Tested Sample Types:
Serum, plasma and other biological fluids
Type:
Sandwich-ELISA
UNIProt ID:
Q8K4C5
Usage:
This ELISA kit applies to the in vitro quantitative determination of Mouse IL-17C concentrations in serum, plasma and other biological fluids.