Elabscience

LAMA-84 Cell Line

Product Code:
CL-0961
Product Group:
Cell Lines
Supplier:
Elabscience
Host Type:
Human
Regulatory Status:
RUO
Shipping:
Dry Ice
Storage:
For long-term cryopreservation, cryovials should be stored in liquid nitrogen at -150°C to -196°C. Storage at -80°C is restricted to short-term interim use only.
 

No additional charges, what you see is what you pay! *

Show prices   How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges to UK mainland customers, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: China.
Typical lead time: 14-21 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • Related Products
  • Show All

Further Information

Age Gender:
29Y, Female
Antigen expression:
GPIIb/IIIa+, GPIIIa+
Background:
LAMA-84 is a human cell line derived from the peripheral blood of a patient with chronic myeloid leukemia (CML) in blast crisis. This cell line is characterized by the presence of the Philadelphia chromosome, which gives rise to the BCR-ABL fusion gene, a hallmark of CML. The BCR-ABL oncogene is known for its role in elevating tyrosine kinase activity, which activates multiple signaling pathways leading to uncontrolled cell proliferation and resistance to apoptosis. Therefore, LAMA-84 cells are a valuable model for studying the molecular mechanisms of CML progression and for evaluating the efficacy of tyrosine kinase inhibitors (TKIs) in preclinical settings. In research, LAMA-84 has been extensively used to investigate the biology of CML, particularly with regard to drug resistance and disease evolution. Studies using this cell line have helped elucidate cellular responses to different generations of TKIs, such as imatinib, dasatinib, and nilotinib. Furthermore, LAMA-84 has contributed to the development of novel therapeutic strategies aimed at overcoming TKI resistance, including the evaluation of combination therapies that target other signaling pathways synergistically dysregulated by the BCR-ABL fusion protein.
Biosafety Level:
BSL-1
Cryopreservation:
General Freezing Medium [PB180436]
Culture medium:
RPMI-1640 [PM150110]+20% Nutrient+1% Supplement
Growth properties:
Suspension
Incubation Atmosphere:
Air, 95%; CO2, 5%,37°C
Medium Renewal:
every 2 to 3 days
Morphology:
Lymphoblast-like; round; single cells
Subcultivation Ratio:
1x10^5-1x10^6 cells/mL
Tissue:
Peripheral blood

Documents