ProSci

Human GAS-6 Recombinant Protein (86-042)

Product Code:
PSI-86-042
Product Group:
Recombinant Proteins
Supplier:
ProSci
Regulatory Status:
RUO
Target Species:
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunogen
  • SDS-PAGE
  • Western Blot (WB)
Shipping:
RT
Storage:
Store at -20°C. Store the lyophilized protein at -20°C to -80 °C up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
 

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This product comes from: United States.
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Further Information

Application Note:
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity Test
Background:
GAS-6 is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest . Gas6 and the structurally related Protein S are vitamin K-dependent and have an extensively gamma -carboxylated N-terminal Gla domain, four EGF-like repeats, and a C-terminal region with homology to steroid hormone binding globulin (SHBG) . Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer . Human Gas6 interacts with both mouse and rat orthologs of these receptors . The full length isoform may be cleaved, resulting in release of the free SHBG region which can independently activate Axl . Shed soluble forms of Axl and Mer bind Gas6 and function as decoy receptors . Gas6 induces a variety of responses, including prevention of apoptosis , cell proliferation , platelet-mediated thrombosis , retinal epithelial cell phagocytosis of outer rod segments , inhibition of VEGF-induced endothelial cell chemotaxis , and the differentiation and expansion of NK cell precursors . The affinity of Gas6 for phosphatidylserine likely contributes to its role in promoting the phagocytosis of apoptotic cells . Several of these effects have been shown to require gamma -carboxylation of the Gla domain .
Buffer:
Lyophilized from a 0.22 um filtered solution of PBS, pH 7.4.
NCBI Gene ID:
2621
Physical State:
Lyophilized
Predicted MW:
70.60 kDa
Protein Accession:
NP_000811
Source Species:
HEK293 cells
SwissProt:
Q14393-2

Documents