Human HRG/HPRG Recombinant Protein (85-790)

Product Code:
PSI-85-790

Supplier:
ProSci

Regulatory Status:
RUO

Target Species:
Human

Applications:

Enzyme-Linked Immunosorbent Assay (ELISA)
Immunogen
SDS-PAGE
Western Blot (WB)

Shipping:
RT

Storage:
Store at -20°C. Store the lyophilized protein at -20°C to -80 °C up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

No additional charges, what you see is what you pay! *

Show prices How to order with us Contact us

Further Information

Application Note:

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity Test

Background:

Histidine-rich glycoprotein, also known as HRG and HPRG, is a glycoprotein located in plasma and platelets and contains an unusually large amount of histidine and proline.The specific functions of HRG remain unclear, but it is known that the protein binds heme, dyes, and divalent metal ions. It inhibits rosette formation and interacts with heparin, thrombospondin, and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis, and the reduction of inhibition of coagulation indicate a potential prothrombotic effect. HPRG is evolutionarily, functionally, and structurally related to cleaved high molecular weight kininogen (HKa), an anti-angiogenic polypeptide that stimulates apoptosis of proliferating endothelial cells through binding to cell-surface tropomyosin. The antiangiogenic activity of the multidomain plasma protein HPRG is localized to its histidine-proline-rich (H/P) domain and has recently been shown to be mediated, at least partially, through binding to cell-surface tropomyosin in fibroblast growth factor-2-activated endothelial cells.

Buffer:

Lyophilized from a 0.22 um filtered solution of PBS, pH 7.4.

NCBI Gene ID:

3273

Physical State:

Lyophilized

Predicted MW:

58.50 kDa

Protein Accession:

NP_000403.1

Source Species:

HEK293 cells

SwissProt:

P04196

Documents

Datasheet