ProSci

Human IFN-alpha I/IFN17 Recombinant Protein (85-884)

Product Code:
PSI-85-884
Product Group:
Recombinant Proteins
Supplier:
ProSci
Regulatory Status:
RUO
Target Species:
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunogen
  • SDS-PAGE
  • Western Blot (WB)
Product Types:
  • Cytokines and Other Signalling
  • IFNs
Shipping:
RT
Storage:
Store at -20°C. Store the lyophilized protein at -20°C to -80 °C up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
 

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This product comes from: United States.
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Further Information

Application Note:
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity Test
Background:
Interferons (IFN) are a family of cytokines with potent antiviral, antiproliferative and immunomodulatory properties, classified based on their binding specificity to cell surface receptors . Human IFNA2 was originally cloned in the early '80s and now more than a dozen closely related IFN alpha subtypes have been identified in both the human and mouse genome, each sharing about 80% amino acid (aa) sequence homology . Structurally, type I IFNs belong to the class of five helicalbundle cytokines, with the IFNA subtypes containing 2 conserved disulfide bonds . There is not a mouse homolog for IFNA17, but mature human IFNA17 shares 58% aa sequence identity with chimpanzee IFNA17. The type I IFNs bind to the interferon alpha receptor (IFNAR), which consists of two subunits: IFNAR1 (alpha -subunit) and IFNAR2 (beta -subunit) . Individual IFNA subtypes are known to display unique efficacies to viral protection . IFNA17 has been shown to be potent against HIV-1 activity . Human IFNA17 is the only IFNA subtype identified with antiviral activity but a reduced ability to activate NK cells . A mutation in IFNA17, Ile184Arg, is associated with an increased risk for cervical cancer.
Buffer:
Lyophilized from a 0.22 um filtered solution of PBS, pH 7.4.
NCBI Gene ID:
3451
Physical State:
Lyophilized
Predicted MW:
20.14 kDa
Protein Accession:
NP_067091.1
Source Species:
HEK293 cells
SwissProt:
P01571

Documents