ProSci

Human KLRG1/CLEC15A/CD369 Recombinant Protein (85-574)

Product Code:
PSI-85-574
Product Group:
Recombinant Proteins
Supplier:
ProSci
Regulatory Status:
RUO
Target Species:
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunogen
  • SDS-PAGE
  • Western Blot (WB)
Shipping:
RT
Storage:
Store at -20°C. Store the lyophilized protein at -20°C to -80 °C up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
 

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This product comes from: United States.
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Further Information

Application Note:
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity Test
Background:
KLRG1 (killer cell lectin-like receptor G1), also called MAFA (mast cell function associated), is an inhibitory type II transmembrane glycoprotein of the C-type lectin family, designated CLEC15A.Within the ECD, Human KLRG1 shares 57% and 80% aa sequence identity with mouse and rat KLRG1, respectively.KLRG1 is expressed on subpopulations of CD8+, CD4+, regulatory, and gamma/delta T cells as well as on NK cells. KLRG1 is expressed on T cells found in cord blood, but it is down regulated postnatally and is subsequently re-expressed on antigen-exposed T cells. It is expressed by a greater proportion of CD8+ T cells in the elderly and by virus specific CD8+ T cells during chronic virus infection. KLRG1 binds to E-, N-, and R-Cadherins, triggering ITIM-dependent KLRG1 signaling and inhibition of T cell activation. The response is bi-directional, as KLRG1 binding to E Cadherin on dendritic cells (DC) can induce an anti-inflammatory DC phenotype (increased IL-10 production and decreased IL-6 and TNF- alpha production).
Buffer:
Lyophilized from a 0.22 um filtered solution of PBS, pH 7.4.
NCBI Gene ID:
10219
Physical State:
Lyophilized
Predicted MW:
41.11 kDa
Protein Accession:
NP_001316028.1
Source Species:
HEK293 cells
SwissProt:
Q96E93

Documents