ProSci

Human Mature BMP-10 Recombinant Protein (85-132)

Product Code:
PSI-85-132
Product Group:
Recombinant Proteins
Supplier:
ProSci
Regulatory Status:
RUO
Target Species:
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunogen
  • SDS-PAGE
  • Western Blot (WB)
Product Type:
Growth Factors
Shipping:
RT
Storage:
Store at -20°C. Store the lyophilized protein at -20°C to -80 °C up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
 

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This product comes from: United States.
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Further Information

Application Note:
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity Test
Background:
BMP-10 is critical for the proper development of the heart but is not expressed until after cardiac patterning or looping are completed. BMP-10 production appears at the onset of trabeculation and chamber formation and is restricted to the right atrium in the adult heart . Homozygous BMP-10 knockout mice die in utero due to arrested cardiac development. BMP-10 is required for the expression of the cardiogenic transcription factors NKX2.5 and MEF2C in developing myocardium and the growth of embryonic cardiomyocytes. NKX2.5 itself negatively regulates BMP-10 expression in cardiac myocytes. Multiple human congenital heart defects result from mutations in NKX2.5 and require BMP-10 expression . In mice, genetic knockout of ErbB leads to a similar phenotype but appears not to involve BMP-10, and knockout of the calcium channel subunit FKBP12 induces BMP-10 over-expression. BMP-10 in the postnatal heart promotes increased cardiomyocyte and heart size. BMP-10 has been shown to signal through ALK-1, BMPR-IA, BMPR-IB, and BMPR-II in transfectants and non-cardiac cell lines . A functional BMP-10 receptor in the heart has not yet been identified, although deletion of BMPR-IA causes similar cardiac morphogenetic abnormalities. In dermal endothelial cells, BMP-10 induces migration, proliferation, and gene expression typically associated with ALK-1.
Buffer:
Lyophilized from 0.22um filtered solution in 4mM HCl.
NCBI Gene ID:
27302
Physical State:
Lyophilized
Predicted MW:
12.16 KDa
Protein Accession:
NP_055297.1
Source Species:
HEK293 cells
SwissProt:
O95393

Documents