Human SIRP-beta 1/CD172b Recombinant Protein (85-412)

Product Code:
PSI-85-412

Supplier:
ProSci

Regulatory Status:
RUO

Target Species:
Human

Applications:

Enzyme-Linked Immunosorbent Assay (ELISA)
Immunogen
SDS-PAGE
Western Blot (WB)

Shipping:
RT

Storage:
Store at -20°C. Store the lyophilized protein at -20°C to -80 °C up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

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Further Information

Application Note:

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity Test

Background:

Signal-regulatory protein beta-1 (SIRP beta 1) also known as SIRP1, belongs to signal-regulatory-protein (SIRP) family, and immunoglobulin superfamily.Signal-regulatory proteins (SIRPs) are cell-surface glycoproteins expressed on myeloid and neural cells that have been shown to recruit SH2 domain-containing protein phosphatase 1 (SHP-1) and SHP-2 and to regulate receptor tyrosine kinase-coupled signaling. SIRP are classified as SIRP alpha molecules, containing 11- to 113-amino acid long, or SIRP beta molecules, with a 5-amino acid long intracytoplasmic domain. SIRP beta 1 is a new DAP12-associated receptor involved in the activation of myeloid cells, which contains a short cytoplasmic domain that lacks sequence motifs capable of recruiting SHP-1 and SHP-2. SIRP beta 1 acts as an activating isoform of SIRP alpha molecules, confirming the co-existence of inhibitory ITIM-bearing molecules, recruiting SHP-1 and SHP-2 protein tyrosine phosphatases, and activating counterparts, whose engagement couples to protein tyrosine kinases via ITAM-bearing molecules.

Buffer:

Lyophilized from a 0.22 um filtered solution of PBS, pH 7.4.

NCBI Gene ID:

10326

Physical State:

Lyophilized

Predicted MW:

38.10 kDa

Protein Accession:

NP_006056.2

Source Species:

HEK293 cells

SwissProt:

O00241

Documents

Datasheet