Mouse Cathepsin S/CTSS Recombinant Protein (85-647)

Product Code:
PSI-85-647

Supplier:
ProSci

Regulatory Status:
RUO

Target Species:
Mouse

Applications:

Enzyme-Linked Immunosorbent Assay (ELISA)
Immunogen
SDS-PAGE
Western Blot (WB)

Shipping:
RT

Storage:
Store at -20°C. Store the lyophilized protein at -20°C to -80 °C up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.

No additional charges, what you see is what you pay! *

Show prices How to order with us Contact us

Further Information

Application Note:

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity Test

Background:

Cathepsin S (CTSS), one of the lysosomal proteinases, has many important physiological functions in the nervous system, especially in process of extracellular matrix degradation and endocellular antigen presentation. Cathepsin S is expressed in the lysosome of antigen presenting cells, primarily dendritic cells, B-cells and macrophages. Cathepsin S is most well known for its critical function in the proteolytic digestion of the invariant chain chaperone molecules, thus controlling antigen presentation to CD4+ T-cells by major histocompatibility complex (MHC) class II molecules or to NK1.1+ T-cells via CD1 molecules. Cathepsin S also appears to participate in direct processing of exogenous antigens for presentation by MHC class II to CD4+ T-cells, or in cross-presentation by MHC class I molecules to CD8+ T-cells. In addition, it has been implicated in the pathogenesis of several diseases such as Alzheimer's disease and degenerative disorders associated with the cells of the mononuclear phagocytic system.

Buffer:

Lyophilized from a 0.22 um filtered solution of PBS, pH 7.4.

NCBI Gene ID:

13040

Physical State:

Lyophilized

Predicted MW:

37.28 kDa

Protein Accession:

NP_067256.4

Source Species:

HEK293 cells

SwissProt:

O70370

Documents

Datasheet