ProSci

SARS-CoV-2 (COVID-19) Spike P26S Antibody [5G12G11] (Gamma Variant)

Product Code:
PSI-PM-9590
Product Group:
Primary Antibodies
Supplier:
ProSci
Host Type:
Mouse
Antibody Isotype:
IgG1
Antibody Clonality:
Monoclonal
Antibody Clone:
5G12G11
Regulatory Status:
RUO
Target Species:
SARS-CoV-2
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Product Type:
Microbial and Virus Specific
Shipping:
RT
Storage:
Store at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 

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Further Information

Application Note:
WB: 1 ug/mL. Antibody validated: Western Blot in human samples. Anti-SARS-CoV-2 Spike P26S (Gamma Variant) antibody specifically detects SARS-CoV-2 Gamma Variant (P.1) Spike S1 protein, but not SARS-CoV-2 WT and other variant Spike S1 protein by ELISA. All other applications and species not yet tested.
Background:
In January of 2021 a new lineage of SARS-CoV-2, known as P.1 and named Gamma variant, was discovered in Japan and later spread in Brazil. It is considered a VOC (variant of concern). This variant carries 10 mutations in spike protein, including N501Y, E484K and K417T in RBD, which can increase the affinity to the human ACE2 receptor. Enhanced transmission of the Gamma variant (P.1 lineage) was observed globally, which is 3.5 times more contagious as the original one. The Gamma variant affects the effectiveness of COVID19 vaccine and is resistant to neutralization to some extent due to the immune escape E484K mutation.
Buffer:
SARS-CoV-2 Spike P26S (Gamma Variant) antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
Homology:
Predicted reactivity based on immunogen sequence: SARS-CoV Spike proteins: (36.4%)
NCBI Gene ID:
43740568
NCBI Name:
surface glycoprotein
NCBI Symbol:
S
Physical State:
Liquid
Protein Accession:
QHD43416
Purification:
Anti-SARS-CoV-2 Spike P26S (Gamma Variant) antibody is immunoaffinity chromatography purified IgG.
Specificity:
It can only detect SARS-CoV-2 Gamma Variant (P.1) Spike S1 protein and does not cross-react with the spike protein of other variants.
SwissProt:
P0DTC2

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