Syntrophin alpha 1 Rabbit Recombinant Antibody (81-623)

WB,1:500 - 1:2000|ELISA,Recommended starting concentration is 1 ug/mL. Please optimize the concentration based on your specific assay requirements.

Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue.

Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Batch dependent

Unconjugated

6640

SNTA1

Liquid

54kDa

Q13424

Q13424