AdipoGen Life Sciences

TRAIL-R1 to -R4 Flow Cytometry Pack

Product Code:
 
AG-44B-0004
Product Group:
 
Antibody Detection Sets
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Flow Cytometry
Shipping:
 
Blue Ice
Storage:
 
Short term: +4°C. Long term: -20°C
 

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This product comes from: Switzerland.
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Further Information

EClass:
32160000
Handling Advice:
After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.
Kit Contains:
100µg each of: anti-TRAIL-R1 (clone HS101, Prod. No. AG-20B-0022 | anti-TRAIL-R2 (clone HS201, Prod. No. AG-20B-0023) | anti-TRAIL-R3 (clone HS301, Prod. No. AG-20B-0024) | anti-TRAIL-R4 (clone HS402, Prod. No. AG-20B-0025)
Long Description:
Set. TRAIL-R1, -R2, -R3 and -R4 are receptors for the cytotoxic ligand TRAIL. When signaling through TRAIL-R1 and -R2, the adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. They promote the activation of NF-kappaB. TRAIL-R3 lacks a cytoplasmic death domain, and TRAIL-R4 contains a truncated death domain, and hence are not capable of inducing apoptosis. They protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
Package Type:
Plastic Vial
Product Description:
TRAIL-R1, -R2, -R3 and -R4 are receptors for the cytotoxic ligand TRAIL. When signaling through TRAIL-R1 and -R2, the adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. They promote the activation of NF-kappaB. TRAIL-R3 lacks a cytoplasmic death domain, and TRAIL-R4 contains a truncated death domain, and hence are not capable of inducing apoptosis. They protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
Transportation:
Non-hazardous
UNSPSC Category:
General Purpose Cell Biology Kits
UNSPSC Number:
41116111
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C.