AdipoGen Life Sciences

H-8 . dihydrochloride

Product Code:
 
AG-CR1-0001
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
Short term: +4°C. Long term: +4°C
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Chemical Structure
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Chemical Structure

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AG-CR1-0001-M01010 mg£46.00
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AG-CR1-0001-M05050 mg£146.00
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  • Further Information
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Further Information

Alternate Names/Synonyms:
N-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide . 2HCl
Appearance:
White to off-white solid.
CAS:
113276-94-1
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C12H15N3O2S.2ClH/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12;;/h2-6,9,13,15H,7-8H2,1H3;2*1H
InChiKey:
RJJLZYZEVNCZIW-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 113276-94-1. Formula: C12H15N3O2S . 2HCl. MW: 265.3 . 72.9. Potent cAMP- and cGMP-dependent protein kinase (PKA and PKG) inhibitor. Myosin light chain kinase (MLCK) inhibitor. Tool to study protein crystal structure-inhibitor interactions.
MDL:
MFCD00036962
Molecular Formula:
C12H15N3O2S . 2HCl
Molecular Weight:
265.3 . 72.9
Package Type:
Vial
Product Description:
Potent cAMP- and cGMP-dependent protein kinase (PKA and PKG) inhibitor [1, 2, 4]. Myosin light chain kinase (MLCK) inhibitor [3]. Tool to study protein crystal structure-inhibitor interactions [5].
Purity:
>98% (NMR)
SMILES:
[Cl-].[Cl-].C[NH2+]CC[NH2+]S(=O)(=O)C1=CC=CC2=CN=CC=C12
Solubility Chemicals:
Soluble in DMSO or 100% ethanol (slightly soluble).
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.

References

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C: H. Hidaka, et al.; Biochemistry 23, 5036 (1984) | Naphthalenesulfonamides as calmodulin antagonists and protein kinase inhibitors: M. Inagaki, et al.; Mol. Pharmacol. 29, 577 (1986) | Specific binding of a novel compound, N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide (H-8) to the active site of cAMP-dependent protein kinase: M. Hagiwara, et al.; Mol. Pharmacol. 31, 523 (1987) | Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives: M. Hagiwara, et al.; Mol. Pharmacol. 32, 7 (1987) | Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity: R.A. Engh, et al.; J. Biol. Chem. 271, 26157 (1996)