Chemodex

7-Methoxy-4-(trifluoromethyl)coumarin

Product Code:
 
CDX-M0015
Product Group:
 
Dyes, Stains, and Probes
Supplier:
 
Chemodex
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
Short term: +4°C. Long term: -20°C
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Chemical Structure
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Chemical Structure

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CDX-M0015-M05050 mg£100.00
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CDX-M0015-M250250 mg£383.00
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Further Information

Alternate Names/Synonyms:
MFC; Methyl 4-(trifluoromethyl)umbelliferyl ether
Appearance:
White powder.
CAS:
575-04-2
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light and moisture.
Hazards:
H315, H319, H335
InChi:
InChI=1S/C11H7F3O3/c1-16-6-2-3-7-8(11(12,13)14)5-10(15)17-9(7)4-6/h2-5H,1H3
InChiKey:
HAZHUELNIGDYQH-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 575-04-2. Formula: C11H7F3O3. MW: 244.17. Synthetic. Fluorescent substrate for oxidoreductases, especially for Cytochrome P450.
MDL:
MFCD00132980
Molecular Formula:
C11H7F3O3
Molecular Weight:
244.17
Package Type:
Vial
Precautions:
P261, P305, P351, P338
Product Description:
Fluorescent substrate for oxidoreductases, especially for Cytochrome P450 family members CYP2C9, CYP2C19, and CYP2E1. Spectral data: lambdaex=333nm; lambdaem=416nm (in methanol). Has been used extensively in high-throughput screens in fluorometric p450 activity assays, and is metabolized to the fluorescent metabolite 7-Hydroxy-4-trifluoromethylcoumarin (HFC) with lambdaex=410nm; lambdaem=538nm.
Purity:
>99% (TLC)
Signal word:
Warning
SMILES:
COC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F
Solubility Chemicals:
Soluble in ethanol, methanol, DMSO or DMF.
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Fluorescent Reagents
UNSPSC Number:
41105331
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

(1) M. Matsui, et al.; Chem. Ber. 125, 467 (1992) | (2) D.M. Stresser, et al.; Drug Metab. Dispos. 30, 845 (2002) | (3) A.Ghosal, et al.; Biopharm. Drug Dispos. 24, 375 (2003) | (4) M.T. Donato, et al.; Drug Metabol. Dispos. 32, 699 (2004) | (5) M.A. Hummel, et al.; J. Biomol. Scr. 11, 303 (2006) | (6) D. Jacquemin, et al.; J. Chem. Phys. 125, 164324 (2006) | (7) I. Kaminska, et al.; Polymer Test. 55, 310 (2016)