ProSci

CD80 Antibody [3H5] (PE)

Product Code:
PSI-76-049
Product Group:
Primary Antibodies
Supplier:
ProSci
Host Type:
Mouse
Antibody Isotype:
Mouse IgG1, kappa
Antibody Clonality:
Monoclonal
Antibody Clone:
3H5
Regulatory Status:
RUO
Target Species:
Rat
Application:
Flow Cytometry
Product Types:
  • Immune Checkpoint
  • Tagged
Storage:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
 

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Further Information

Additional Names:
B7-1, Cd80
Background:
The 3H5 monoclonal antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. The 3H5 antibody blocks the binding of CD80 to its ligands.
Background References:
  • Damoiseaux, J. G., Yagita, H., Okumura, K., van Breda Vriesman, P. J. (1998). Costimulatory molecules CD80 and CD86 in the rat
  • Maeda, K., Sato, T., Azuma, M., Yagita, H., Okumura, K. (1997). Characterization of rat CD80 and CD86 by molecular cloning and mAb.International immunology,9(7), 993-1000.
  • Bluestone, J. A. (1995). New perspectives of CD28-B7-mediated T cell costimulation.Immunity,2(6), 555-559.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
PE
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
25408
NCBI Official Name:
Cd80 molecule
NCBI Official Symbol:
Cd80
NCBI Organism:
Rattus norvegicus
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Innate Immunity,Immunology
SPECIFICITY:
The 3H5 monoclonal antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR).
User NOte:
Optimal dilutions for each application to be determined by the researcher.