Chimerigen

IL-10 (human) (rec.) (His)

Product Code:
 
CHI-HF-20110
Product Group:
 
Recombinant Proteins
Supplier:
 
Chimerigen
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Activity Assay
Shipping:
 
Blue Ice
Storage:
 
Short term: +4°C. Long term: -20°C
 

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CHI-HF-20110-C01010 ug£236.00
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Further Information

Alternate Names/Synonyms:
Interleukin-10; Cytokine Synthesis Inhibitory Factor; CSIF
Biological Activity:
Determined by the dose-dependent co-stimulation (with human IL-4) of MC/9 cells. The ED50 was found to be < 2.0 ng/ml, corresponding to a specific activity of > 5 x 105 units/mg.
EClass:
32160000
Endotoxin:
<0.01EU/µg protein (LAL test; Lonza).
Form (Short):
liquid
Formulation:
Lyophilized from 0.2µm-filtered solution in PBS.
Handling Advice:
Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1% BSA should be used for further dilutions.
Long Description:
Protein. Human IL-10 (aa 19-178) is fused at the C-terminus to a His-tag. Source: HEK 293 cells. Endotoxin content: <0.01EU/µg protein (LAL test; Lonza). Lyophilized from 0.2µm-filtered solution in PBS. Purity: >95% (SDS-PAGE). Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases.
Molecular Weight:
~18kDa (SDS-PAGE)
NCBI, Uniprot Number:
NP_000563.1
Package Type:
Plastic Vial
Product Description:
Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases.
Purity:
>95% (SDS-PAGE)
Sequence:
Human IL-10 (aa 19-178) is fused at the C-terminus to a His-tag.
Source / Host:
HEK 293 cells
TAGs:
His
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.