Chemodex

Levocetirizine dihydrochloride

Product Code:
 
CDX-L0121
Product Group:
 
Other Biochemicals
Supplier:
 
Chemodex
Antibody Isotype:
 
n/a
Antibody Clone:
 
n/a
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
Short term: +20°C. Long term: +20°C
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Chemical Structure
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Chemical Structure

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CDX-L0121-M01010 mg£56.00
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CDX-L0121-M05050 mg£182.00
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Further Information

Alternate Names/Synonyms:
(R)-Cetirizine dihydrochloride; (-)-Cetirizine dihydrochloride; 2-[2-[4-[(R)-(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid dihydrochloride
Appearance:
Solid.
CAS:
130018-87-0
Class:
9
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07,GHS09
Handling Advice:
Protect from light and moisture.
Hazards:
H302-H400
InChi:
InChI=1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H/t21-;;/m1./s1
InChiKey:
PGLIUCLTXOYQMV-GHVWMZMZSA-N
Long Description:
Chemical. CAS: 130018-87-0. Formula: C21H25ClN2O3 . 2HCl. MW: 461.81. Levocetirizine hydrochloride is the (R)-enantiomer of the histamine H1 receptor antagonist and antihistamine agent cetirizine. It binds to the H1 receptor with higher affinity than cetirizine and is 25,000-100,000-fold selective for H1 receptors over muscarinic M1-M5 receptors. Intranasal administration dose-dependently decreases histamine-induced nasal rubbing and sneezing in mice. Has been used in the treatment of allergic rhinitis and chronic idiopathic urticaria.
MDL:
MFCD07366507
Molecular Formula:
C21H25ClN2O3 . 2HCl
Molecular Weight:
461.81
Package Type:
Vial
PG:
III
Precautions:
P273
Product Description:
Levocetirizine hydrochloride is the (R)-enantiomer of the histamine H1 receptor antagonist and antihistamine agent cetirizine. It binds to the H1 receptor with higher affinity than cetirizine and is 25,000-100,000-fold selective for H1 receptors over muscarinic M1-M5 receptors. Intranasal administration dose-dependently decreases histamine-induced nasal rubbing and sneezing in mice. Has been used in the treatment of allergic rhinitis and chronic idiopathic urticaria.
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
ClC(C=C1)=CC=C1[C@@H](C2=CC=CC=C2)[NH+]3CC[NH+](CCOCC(O)=O)CC3.[Cl-].[Cl-]
Solubility Chemicals:
Soluble in water (20mg/ml).
Source / Host:
Synthetic.
Transportation:
Excepted Quantity
UN Nummer:
3077
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at RT.

References

(1) M. Gillard, et al.; Inflamm. Res. 52, S49 (2003) | (2) L. Zhang, et al.; Pharmacol. 92, 14 (2013) | (3) C. Kitayama-Sugiyama, et al.; Immunotoxicol. 35, 545 (2013) | (4) A. Kanei, et al.; In Vivo 28, 657 (2014)