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2019-nCoV Nucleocapsid Recombinant Protein

Product Code:
PSI-97-077
Product Group:
Recombinant Proteins
Supplier:
ProSci
Host Type:
E.coli
Regulatory Status:
RUO
Target Species:
Human
Application:
Western Blot (WB)
Product Type:
Microbial and Virus Specific
Shipping:
Dry ice
Storage:
-20°C
 

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Further Information

Additional Names:
Nucleocapsid protein, NP, Protein N
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Nucleocapsid protein is a most abundant protein of coronavirus. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. While screening for ADP-ribosylated proteins during coronavirus (CoV) infection, we identified as the viral nucleocapsid (N) protein. Novel post-translation modification of the CoV N protein that may play a regulatory role for this important structural protein. The array of diverse functional activities accommodated in the hantaviral N protein goes far beyond to be a static structural protein and makes it an interesting target in the development of antiviral therapeutics. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.
Background References:
  • Reuter M, et al. Virus Genes. 2018. 54:5-16.
  • Grunewald ME, et al. Virology. 2018. 517:62-68.
  • Jeeva S, et al. PLoS One. 2017. 12(9):e0184935.
Buffer:
Lyophilized from 0.22 um filtered solution in 50 mM Tris, 150 mM NaCl, Arginine, pH7.5. Normally trehalose is added as protectant before lyophilization.
Fusion Tag:
His Tag
NCBI Gene ID #:
43740575
NCBI Official Name:
nucleocapsid phosphoprotein
NCBI Official Symbol:
NS1
NCBI Organism:
Severe acute respiratory syndrome coronavirus 2
Physical State:
Lyophilized
Predicted Molecular Weight:
49.4 kDa
Protein Accession #:
QHO62115.1
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli

Documents