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Further Information
Bioactivity:
TXA6101 is an inhibitor of the bacterial protein FtsZ (filamentous temperature sensitive protein Z). TXA6101 inhibits bacterial division and has an MIC of 1 ug/mL against MRSA isolates expressing either the G193D or G196S mutant FtsZ and retains significant activity against the TXA707 resistant FtsZ mutant. TXA6101 can be used as a potential method of resistance to Gram-negative infections.