Debromohymenialdisine
Product Code: AG-CN2-0068
Product Group: Natural Products and Extracts
Supplier: AdipoGen Life Sciences
| Code | Size | Price |
|---|
| AG-CN2-0068-C100 | 100 ug | £120.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
DBH; DBHA-SKF; SKF 108753
Appearance:
Yellow solid.
CAS:
75593-17-8 and 125118-55-0
EClass:
32160000
Form (Short):
solid
Handling Advice:
Keep cool and dry.Keep under inert gas.Protect from light.
InChi:
InChI=1S/C11H11N5O2/c12-11-15-8(10(18)16-11)6-2-4-14-9(17)7-5(6)1-3-13-7/h1,3,13H,2,4H2,(H,14,17)(H3,12,15,16,18)/b8-6-
InChiKey:
JYRJOQGKGMHTOO-VURMDHGXSA-N
Long Description:
Chemical. CAS: 75593-17-8 and 125118-55-0. Formula: C11H11N5O2. MW: 245.2. Isolated from sponge Axinella carteri. Protein kinase C (PKC) inhibitor. Inhibits the ATP binding site. Cytotoxic and insecticidal. G2 DNA damage checkpoint inhibitor. Check point kinases 1 (Chk1) and 2 (Chk2) inhibitor. Does not inhibit ataxia-telangiectasia mutated (ATM) or ATM-Rad3-related proteins. MAP kinase kinase 1 (MEK-1) inhibitor. Interleukin-1 (IL-1) inhibitor. Anti-osteoarthritic. Potential anti-Alzheimer agent.
MDL:
MFCD04037016
Molecular Formula:
C11H11N5O2
Molecular Weight:
245.2
Package Type:
Vial
Product Description:
Protein kinase C (PKC) inhibitor. Inhibits the ATP binding site [1]. Cytotoxic and insecticidal [2]. G2 DNA damage checkpoint inhibitor. Check point kinases 1 (Chk1) and 2 (Chk2) inhibitor [3, 4, 6]. Does not inhibit ataxia-telangiectasia mutated (ATM) or ATM-Rad3-related proteins [3, 4]. MAP kinase kinase 1 (MEK-1) inhibitor [5]. Interleukin-1 (IL-1) inhibitor. Anti-osteoarthritic [7]. Potential anti-Alzheimer agent [7].
Purity:
>95% (HPLC)
SMILES:
NC1=NC(=O)C(N1)=C1/CCNC(=O)C2=C1C=CN2
Solubility Chemicals:
Soluble in DMSO, ethanol or methanol.
Source / Host:
Isolated from sponge Axinella carteri.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Effects of a protein kinase C inhibitor (PKCI) on the development of adjuvant-induced arthritis (AA) in rats: M. DiMartino, et al.; Inflamm. Res. 44, S123 (1995) | Bioactive alkaloids from the tropical marine sponge Axinella carteri: A. Supriyono, et al.; Z. Naturforsch. C 50, 669 (1995) | Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine: D. Curman, et al.; J. Biol. Chem. 276, 17914 (2001) | G2 DNA damage checkpoint inhibition and antimitotic activity of 13-hydroxy-15-oxozoapatlin: N.T. Rundle, et al.; J. Biol. Chem. 276, 48231 (2001) | Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1): D. Tasdemir, et al.; J. Med. Chem. 45, 529 (2002) | G2 checkpoint abrogators as anticancer drugs: T. Kawabe; Mol. Cancer Ther. 3, 513 (2004) | Cellular localization of debromohymenialdisine and hymenialdisine in the marine sponge Axinella sp. using a newly developed cell purification protocol: Y.F. Song, et al.; Mar. Biotechnol. 13, 868 (2011)