anti-Nitrotryptophan (NW), mAb (117C)
| Code | Size | Price |
|---|
| JAI-MNW-020P-20ug | 20 ug | £233.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Antibody Isotype: Mouse IgG1?
Antibody Clonality: Monoclonal
Antibody Clone: 117C
Regulatory Status: RUO
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
BI
Storage:
-20°C
Documents
Further Information
Concentration:
100µg/ml of IgG in 10mM PBS (pH 7.4).
EClass:
32160000
Form (Short):
liquid
Formulation:
Lyophilized.
Handling Advice:
Avoid freeze/thaw cycles.
Immunogen:
6-Nitrotryptophan modified Keyhole Limpet Hemocyanin (KLH).
Long Description:
Monoclonal Antibody. Recognizes 6-Nitrotryptophan. Lyophilized. Contains 10mM PBS (pH 7.4). Reactive nitrogen species (RNS) are formed in a variety of diseases such as atherosclerosis, inflammation, cancer and neurodegenerative diseases. Peroxinitrite (ONOO-) is known as a potent biological oxidant, which is formed via very fast reaction between nitric oxide (NO) and superoxide (O2-). Peroxinitrite can induce nitration of aromatic amino acids such as Tyr, Trp, Phe and His, which results in modulation of protein functions. To date, 6-nitrotryptophan (6-NO2-Trp) is shown to be one of the most stable and major peroxynitrite-modified amino acids, and growing evidences suggest that nitrotryptophan may play a significant role in the cellular regulation under nitrosative stress. This antibody is suitable for immunohistochemistry, western blotting and ELISA and may provide a powerful tool for the investigation of nitrosative stress inside living bodies.
Package Type:
Plastic Vial
Product Description:
Reactive nitrogen species (RNS) are formed in a variety of diseases such as atherosclerosis, inflammation, cancer and neurodegenerative diseases. Peroxinitrite (ONOO-) is known as a potent biological oxidant, which is formed via very fast reaction between nitric oxide (NO) and superoxide (O2-). Peroxinitrite can induce nitration of aromatic amino acids such as Tyr, Trp, Phe and His, which results in modulation of protein functions. To date, 6-nitrotryptophan (6-NO2-Trp) is shown to be one of the most stable and major peroxynitrite-modified amino acids, and growing evidences suggest that nitrotryptophan may play a significant role in the cellular regulation under nitrosative stress. This antibody is suitable for immunohistochemistry, western blotting and ELISA and may provide a powerful tool for the investigation of nitrosative stress inside living bodies.
Purity:
Protein A purified.
Specificity:
Recognizes 6-Nitrotryptophan.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 3 years after receipt when stored at -20°C.
References
Proteomic analysis of endogeneous nitrotryptophan-containing proteins in rat hippocampus and cerebellum: M. Uda, et al.; Bioci. Rep. 32, 521 (2012)
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