ProSci

TCTN1 Antibody

Product Code:
 
PSI-5833
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
1 / 3
Western blot analysis of TCTN1 in mouse kidney tissue lysate with TCTN1 antibody at (A) 1 and (B) 2μg/mL.
2 / 3
Immunohistochemistry of TCTN1 in human kidney tissue with TCTN1 antibody at 5 μg/mL.
3 / 3
Immunofluorescence of TCTN1 in Human Kidney cells with TCTN1 antibody at 20 μg/mL.
❮❯

Western blot analysis of TCTN1 in mouse kidney tissue lysate with TCTN1 antibody at (A) 1 and (B) 2μg/mL.
Immunohistochemistry of TCTN1 in human kidney tissue with TCTN1 antibody at 5 μg/mL.
Immunofluorescence of TCTN1 in Human Kidney cells with TCTN1 antibody at 20 μg/mL.

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CodeSizePrice
PSI-5833-0.02mg0.02mg£150.00
Quantity:
PSI-5833-0.1mg0.1mg£453.00
Quantity:
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Further Information

Additional Names:
TCTN1 Antibody: TECT1, JBTS13, TECT1, UNQ9369/PRO34160, Tectonic-1
Application Note:
TCTN1 antibody can be used for detection of TCTN1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
TCTN1 Antibody: TCTN1 is the founding member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. During embryonic development, TCTN1 is expressed in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.
Background References:
  • Reiter JF and Skarnes WC. Tectonic, a novel regulator of the Hedgehog pathwy required for both activation and inhibition. Genes Dev.2006; 20:22-7.
Buffer:
TCTN1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
TCTN1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human TCTN1.

The immunogen is located within amino acids 30 - 80 of TCTN1.
NCBI Gene ID #:
79600
NCBI Official Name:
tectonic family member 1
NCBI Official Symbol:
TCTN1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_001076007
Protein GI Number:
130978359
Purification:
TCTN1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
Swissprot #:
Q2MV58
User NOte:
Optimal dilutions for each application to be determined by the researcher.