ProSci

TMEM106A Antibody

Product Code:
 
PSI-6781
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
1 / 3
Western blot analysis of TMEM106A in A-20 cell lysate with TMEM106A antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
2 / 3
Immunohistochemistry of TMEM106A in mouse brain tissue with TMEM106A antibody at 5 μg/mL.
3 / 3
Immunofluorescence of TMEM106A in mouse brain tissue with TMEM106A antibody at 20 μg/mL.
❮❯

Western blot analysis of TMEM106A in A-20 cell lysate with TMEM106A antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry of TMEM106A in mouse brain tissue with TMEM106A antibody at 5 μg/mL.
Immunofluorescence of TMEM106A in mouse brain tissue with TMEM106A antibody at 20 μg/mL.

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CodeSizePrice
PSI-6781-0.02mg0.02mg£150.00
Quantity:
PSI-6781-0.1mg0.1mg£449.00
Quantity:
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Further Information

Additional Names:
TMEM106A Antibody: Transmembrane protein 106A
Application Note:
TMEM106A antibody can be used for detection of TMEM106A by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 5 μg/mL.

Antibody validated: Western Blot in mouse samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
TMEM106A Antibody: Transmembrane protein 106A (TMEM106A) is a single-pass transmembrane protein that is closely related to TMEM106B, a protein that is thought to be a novel risk factor for frontotemporal lobar degeneration (FTLD), a group of clinically, pathologically and genetically heterogeneous disorders associated with atrophy in the frontal lobe and temporal lobe of the brain. The actual roles of TMEM106A and TMEM106B are still undetermined; however, as TMEM106B is involved in FTLD, it is possible that TMEM106A may also be a risk factor for FTLD.
Background References:
  • Van Deerlin VM, Sleiman PM, Martinez-Lage M, et al. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat. Genet. 2010; 42:234-9
  • Aswathy PM, Jairani PS, and Mathuranath PS. Genetics of frontotemporal lobar degeneration. Ann. Indian Acad. Neurol. 2010; 13(Suppl 2):S55-62.
Buffer:
TMEM106A Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
TMEM106A antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human TMEM106A.

The immunogen is located within the first 50 amino acids of TMEM106A.
NCBI Gene ID #:
113277
NCBI Official Name:
transmembrane protein 106A
NCBI Official Symbol:
TMEM106A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_659478
Protein GI Number:
21450796
Purification:
TMEM106A Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
Swissprot #:
Q96A25
User NOte:
Optimal dilutions for each application to be determined by the researcher.