ProSci

SGSM1 Antibody

Product Code:
 
PSI-7033
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Western Blot (WB)
1 / 2
Western blot analysis of SGSM1 in human cerebellum tissue lysate with SGSM1 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
2 / 2
Immunofluorescence of SGSM1 in human brain tissue with SGSM1 antibody at 20 μg/mL.
❮❯

Western blot analysis of SGSM1 in human cerebellum tissue lysate with SGSM1 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
Immunofluorescence of SGSM1 in human brain tissue with SGSM1 antibody at 20 μg/mL.

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CodeSizePrice
PSI-7033-0.02mg0.02mg£150.00
Quantity:
PSI-7033-0.1mg0.1mg£453.00
Quantity:
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Further Information

Additional Names:
SGSM1 Antibody: RUTBC2, KIAA1941, RUTBC2, Small G protein signaling modulator 1, RUN and TBC1 domain-containing protein 2
Application Note:
SGSM1 antibody can be used for detection of SGSM1 by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
SGSM1 Antibody: Small G proteins such as RAP and RAB proteins are the key molecules in intracellular signal transduction and vesicle transportation. A novel protein family small G protein signaling modulator (SGSM) consisting of three members SGSM1-3 bind to RAP and RAB family proteins. All three SGSM proteins possess both a RUN domain and a TBC domain. SGSM1 (RUTBC2) is a 1,148 amino acid protein that localizes to the Golgi apparatus and is mainly expressed in the CNS. SGSM1 interacts with RAP and RAB subfamily members of the small G proteins, and function as modulators of RAP and RAB-mediated neuronal signal transduction and vesicular transportation pathways.
Background References:
  • Bar-Sagi D and Hall A. Ras and Rho GTPases: a family reunion. Cell 2000; 103:227-38.
  • Colicelli J. Human ras superfamily proteins and related GTPases. Sci. STKE 2004; 250:RE13.
  • Yang H, Sasaki T, Minoshima S, et al. Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway. Genomics 2007; 90:249-60.
  • Williams JA, Chen X and Sabbatini ME. Small G proteins as key regulators of pancreatic digestive enzyme secretion. Am. J. Physiol. Endocrinol. Metab. 2009; 296:E405-14.
Buffer:
SGSM1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
SGSM1 antibody was raised against a 17 amino acid synthetic peptide near the center of human SGSM1.

The immunogen is located within amino acids 480 - 530 of SGSM1.
NCBI Gene ID #:
129049
NCBI Official Name:
small G protein signaling modulator 1
NCBI Official Symbol:
SGSM1
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
126 kDa
Protein Accession #:
NP_001035037
Protein GI Number:
90577167
Purification:
SGSM1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
At least four isoforms of SGSM1 are known to exist; SGSM1 antibody will detect all four isoforms.
Swissprot #:
Q2NKQ1
User NOte:
Optimal dilutions for each application to be determined by the researcher.