Aloesin
Product Code: AG-CN2-0437
Product Group: Natural Products and Extracts
Supplier: AdipoGen Life Sciences
| Code | Size | Price |
|---|
| AG-CN2-0437-C500 | 500 ug | £90.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
Aloeresin B
Appearance:
Pale yellow to brown sticky solid.
CAS:
30861-27-9
EClass:
32160000
Form (Short):
solid
Handling Advice:
Protect from light.
InChi:
InChI=1S/C19H22O9/c1-7-3-10(22)14(19-17(26)16(25)15(24)12(6-20)28-19)18-13(7)11(23)5-9(27-18)4-8(2)21/h3,5,12,15-17,19-20,22,24-26H,4,6H2,1-2H3/t12-,15-,16+,17-,19+/m1/s1
InChiKey:
HKIKAXXIWJHWLY-ZIIYPAMZSA-N
Long Description:
Chemical. CAS: 30861-27-9. Formula: C19H22O9. MW: 394.4. Isolated from Aloe vera. C-glycosylated chromone compound. Tyrosinase inhibitor. Inhibits melanin production. Inhibitor of hyperpigmentation. Antioxidant. Free radical scavenger. Anti-inflammatory compound. Shown to up-regulate cyclin E/CDK2 kinase activity. Hepatoprotective. Stimulates cell proliferation. Anti-diabetic. Increased adiponectin production and improves the insulin sensitivity in db/db and diet-induced obese-diabetic mice.
MDL:
MFCD00869744
Molecular Formula:
C19H22O9
Molecular Weight:
394.4
Package Type:
Vial
Product Description:
C-glycosylated chromone compound. Tyrosinase inhibitor. Inhibits melanin production. Inhibitor of hyperpigmentation. Antioxidant. Free radical scavenger. Anti-inflammatory compound. Shown to up-regulate cyclin E/CDK2 kinase activity. Hepatoprotective. Stimulates cell proliferation. Anti-diabetic. Increased adiponectin production and improves the insulin sensitivity in db/db and diet-induced obese-diabetic mice.
Purity:
>98% (HPLC)
SMILES:
CC(=O)CC1=CC(=O)C2=C(C)C=C(O)C([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)=C2O1
Solubility Chemicals:
Soluble in DMSO or ethanol.
Source / Host:
Isolated from Aloe vera.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Aloesin up-regulates cyclin E/CDK2 kinase activity via inducing the protein levels of cyclin E, CDK2, and CDC25A in SK-HEP-1 cells: K.Y. Lee, et al.; Biochem. Mol. Biol. Int. 41, 285 (1997) | Aloesin inhibits hyperpigmentation induced by UV radiation: S. Choi, et al.; Clin. Exp. Dermatol. 27, 513 (2002) | Modulation of melanogenesis by aloesin: a competitive inhibitor of tyrosinase: K. Jones, et al.; Pigment Cell Res. 15, 335 (2002) | Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera: A. Yagi, et al.; Planta Med. 68, 957 (2002) | Aloeresin I, an anti-inflammatory 5-methylchromone from cape aloe: G. Speranza, et al.; Planta Med. 71, 79 (2005) | Antitumor properties and modulation of antioxidant enzymes' activity by Aloe vera leaf active principles isolated via supercritical carbon dioxide extraction: H.A. El-Shemy, et al.; Curr. Med. Chem. 17, 129 (2010) | UP780, a chromone-enriched aloe composition improves insulin sensitivity: M. Yimam, et al.; Metab. Syndr. Relat. Disord. 11, 267 (2013) | Blood glucose lowering activity of aloe based composition, UP780, in alloxan induced insulin dependent mouse diabetes model: M. Yimam, et al.; Diabetol. Metab. Syndr. 6, 61 (2014) | Phytochemical constituents and in vitro radical scavenging activity of different Aloe species: L. Pucini, et al.; Food Chem. 170, 501 (2014)