3-Deoxyaphidicolin
| Code | Size | Price |
|---|
| BVT-0451-C250 | 250 ug | £85.00 |
Quantity:
| BVT-0451-M001 | 1 mg | £235.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
(+)-3-Deoxyaphidicolin
Appearance:
White to off-white solid.
CAS:
85483-00-7
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light when in solution.
Hazards:
H302, H319
InChi:
InChI=1S/C20H34O3/c1-17(12-21)6-3-7-18(2)16(17)5-4-14-10-15-11-19(14,18)8-9-20(15,23)13-22/h14-16,21-23H,3-13H2,1-2H3/t14-,15+,16-,17-,18-,19-,20-/m0/s1
InChiKey:
VHWTVINEPPOCLA-DTMQFJJTSA-N
Long Description:
Chemical. CAS: 85483-00-7. Formula: C20H34O3. MW: 322.5. Isolated from Phoma sp. BS 7210. Inhibitor of eukaryotic DNA synthesis. Mycotoxin. Phytotoxic and cytotoxic agent. Specific inhibitor of DNA polymerase alpha.
Molecular Formula:
C20H34O3
Molecular Weight:
322.5
Package Type:
Plastic Vial
Precautions:
P270, P280, P301, P312, P305, P351, P338
Product Description:
Inhibitor of eukaryotic DNA synthesis. Mycotoxin. Phytotoxic and cytotoxic agent. Specific inhibitor of DNA polymerase alpha.
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
[H][C@]12C[C@@H]3C[C@]1(CC[C@]3(O)CO)[C@@]1(C)CCC[C@@](C)(CO)[C@]1([H])CC2
Solubility Chemicals:
Soluble in DMSO (50 mg/ml), methanol (10 mg/ml) or 100% ethanol; insoluble in water.
Source / Host:
Isolated from Phoma sp. BS 7210.
Transportation:
Non-hazardous
UNSPSC Category:
Natural Products/Extracts
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 1 year after receipt when stored at +4°C.
References
Specific inhibitors of eukaryotic DNA synthesis and DNA polymerase alpha, 3-deoxyaphidicolin and aphidicolion-17-monoacetate: T. Haraguchi, et al.; Nucleic Acids Res. 11, 1197 (1983) | 3-Deoxyaphidicolin and aphidicolin analogs as phytotoxins from Phoma betae: A. Ichihara, et al.; Agr. Biol. Chem. 48, 1687 (1984) | Phytotoxicity of the new metabolites produced by Phoma betae, the cause of Phoma root rot and leaf spot in sugar beet (Beta vulgaris L.): R. Sakai, et al.; Nippon Shokubutsu Byori Gakkaiho 51, 219 (1985) | An efficient conversion of 1-abietic acid to (+)-3-deoxyaphidicolin: H. Koyama, et al.; Tetrahedron Lett. 26, 2685 (1985) | Chemical modification of aphidicolin and the inhibitory effects of its derivatives on DNA polymerase alpha in vitro: S. Hiranuma, et al.; Chem. & Pharm. Bull. 35, 1641 (1987) | Structure-activity relationships for the inhibition of DNA polymerase alpha by aphidicolin derivatives: G. Prasad, et al.; Nucleic Acids Res. 17, 6339 (1989) | Total biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase alpha: heterologous expression of four biosynthetic genes in Aspergillus oryzae: R. Fujii, et al.; Biosci. Biotech. Bioch. 75, 1813 (2011)
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