Melanin Production Inhibitor A3B5
| Code | Size | Price |
|---|
| AG-CR1-3605-M001 | 1 mg | £140.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
N-(3,5-Dimethylphenyl)-3-methoxybenzamide
Appearance:
White solid.
CAS:
346721-60-6
EClass:
32160000
Form (Short):
solid
GHS Symbol:
GHS07
Handling Advice:
Keep cool and dry.
Hazards:
H319, H335
InChi:
InChI=1S/C16H17NO2/c1-11-7-12(2)9-14(8-11)17-16(18)13-5-4-6-15(10-13)19-3/h4-10H,1-3H3,(H,17,18)
InChiKey:
YOYXSQKGMBWPGK-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 346721-60-6. Formula: C16H17NO2. MW: 255.3. Non-cytotoxic melanogenesis inhibitor. Potential depigmentation agent. Tyrosinase-related protein 2 (TRP-2) expression inhibitor, via proteasomal degradation. Inhibits the proliferation of melanocytes and melanoma cells through cell cycle arrest in G1. Moderate skin tumor growth suppressor in vivo.
MDL:
MFCD01152934
Molecular Formula:
C16H17NO2
Molecular Weight:
255.3
Package Type:
Vial
Precautions:
P261, P271, P280, P312
Product Description:
Non-cytotoxic melanogenesis inhibitor. Potential depigmentation agent. Tyrosinase-related protein 2 (TRP-2) expression inhibitor, via proteasomal degradation. Inhibits the proliferation of melanocytes and melanoma cells through cell cycle arrest in G1. Moderate skin tumor growth suppressor in vivo.
Purity:
>98% (NMR)
Signal Word:
Warning
SMILES:
COC1=CC(=CC=C1)C(=O)NC1=CC(C)=CC(C)=C1
Solubility Chemicals:
Soluble in DMSO or methanol. Insoluble in water.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Identification of a potent and noncytotoxic inhibitor of melanin production: S. Hwang, et al.; Bioorg. Med. Chem. 18, 5602 (2010) | N-(3,5-dimethylphenyl)-3-methoxybenzamide (A(3)B(5)) targets TRP-2 and inhibits melanogenesis and melanoma growth: E.J. Lee, et al.; J. Invest. Dermatol. 131, 1701 (2011)