CD273 [PD-L2] non-lytic Recombinant Protein

ProSci
Product Code: PSI-90-426
Product Group: Recombinant Proteins
Supplier: ProSci

CodeSizePrice
PSI-90-426-100ug100ug£657.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Target Species: Human
Storage:
Stable for at least 1 year after receipt when stored at -20˚C. Working aliquots are stable for up to 3 months when stored at -20˚C.

Documents

Further Information

Additional Names:
PD-L2, Programmed Cell Death 1 Ligand 2, PDCD1 Ligand 2, B7-DC, PDL2
Application Note:
This recombinant proteins is for research use only.
Background:
T cells require a signal induced by the engagement of the T cell receptor and a ??costimulatory?? signal(s) through distinct T cell surface molecules for optimal T cell activation and tolerance. CD273 is one of two ligands for programmed death-1 (PD-1; CD279), a member of the CD28 family of immunoreceptors. The other identified ligand is PD-L1. CD273 is broadly expressed and also up regulated in a variety of tumor cell lines. On previously activated T cells, CD273 interaction with PD-1 inhibits TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. CD273 has a costimulatory function on resting T cells activated with suboptimal TCR signals.
Biological Activity:
Shows the biological function of the CD273 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.
Buffer:
Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 μg/ml in sterile PBS.
Fusion Tag:
Fc Tag
NCBI Gene ID #:
80380
NCBI Official Name:
programmed cell death 1 ligand 2
NCBI Official Symbol:
PDCD1LG2
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_079515
Protein GI Number:
190014605
Purity:
>98% (SDS-PAGE).

Endotoxin level is less than 0.06EU/ μg protein (LAL test; Lonza).
Recombinant Protein Sequence:
Thr32-Gly402
Source:
CHO cells
Swissprot #:
P05112