TIGIT Recombinant Protein

ProSci
Product Code: PSI-92-550
Product Group: Recombinant Proteins
Supplier: ProSci

CodeSizePrice
PSI-92-550-0.05mg0.05mg£488.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Target Species: Mouse
Storage:
Lyophilized protein should be stored at -20˚C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7˚C for 2-7 days.
Aliquots of reconstituted samples are stable at -20˚C for 3 months.

Documents

Further Information

Additional Names:
T-cell immunoreceptor with Ig and ITIM domains, TIGIT, V-set and transmembrane domain-containing protein 3, VSTM3, REF: C1127, VSIG9
Application Note:
This recombinant protein can be used for biological assays. For research use only.
Background:
T cell immunoreceptor with Ig and ITIM domains (TIGIT), also called WUCAM, VSIG9 and Vstm3, is a member of the CD28 family within the Ig superfamily of proteins. TIGIT contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM), and is expressed on regulatory, memory, activated T cells and NK cells. TIGIT binds to CD155(PVR) that appear on dendritic cells (DC), macrophages and endothelium with high affinity, and CD112(PVRL2) with lower affinity, but not CD113 (PVRL3). TIGIT-Fc fusion protein could interact with PVR on DC and enhance the secretion of IL-10, but inhibit the macrophage activation. Mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges, while knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses.
Buffer:
Lyophilized from a 0.2 um filtered solution of PBS, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Fusion Tag:
C-6 His tag
NCBI Gene ID #:
100043314
NCBI Official Name:
T cell immunoreceptor with Ig and ITIM domains
NCBI Official Symbol:
Tigit
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Predicted Molecular Weight:
13.3 kD
Protein Accession #:
P86176
Purity:
Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
Human Cells
Swissprot #:
P86176