AdipoGen Life Sciences

TAK-715

Product Code:
 
SYN-1087
Product Group:
 
Inhibitors and Activators
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
Short term: +4°C. Long term +4°C
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Chemical Structure
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Chemical Structure

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Further Information

Alternate Names/Synonyms:
TAK715
Appearance:
Solid.
CAS:
303162-79-0
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Hazards:
H303, H317, H333
InChi:
InChI=1S/C24H21N3OS/c1-3-21-27-22(18-11-7-8-16(2)14-18)23(29-21)19-12-13-25-20(15-19)26-24(28)17-9-5-4-6-10-17/h4-15H,3H2,1-2H3,(H,25,26,28)
InChiKey:
HEKAIDKUDLCBRU-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 303162-79-0. Formula: C24H21N3OS. MW: 399.5. TAK-715 is a potent specific inhibitor of the p38alpha MAP kinase with an IC(50) of 7.1nM. It is approximately 30-fold more selective for p38alpha over p38beta. It shows no inhibition of p38gamma/delta.
Molecular Formula:
C24H21N3OS
Molecular Weight:
399.5
Package Type:
Plastic Vial
Precautions:
P261, P272, P280, P302, P352, P333, P313, P321, P363, P501
Product Description:
TAK-715 is a potent specific inhibitor of the p38alpha MAP kinase with an IC(50) of 7.1nM. It is approximately 30-fold more selective for p38alpha over p38beta. It shows no inhibition of p38gamma/delta.
Purity:
>95%
Signal word:
Warning
Solubility Chemicals:
Soluble in DMSO or ethanol.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent: S. Miwatashi, et al.; J. Med. Chem. 48, 5966 (2005)