TIGIT Antibody

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ProSci
Product Code: PSI-61-342
Product Group: Primary Antibodies
Supplier: ProSci

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PSI-61-342-200ul200ul£626.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
  • Human
  • Mouse
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western Blot at 1:2000 dilution Lane 1: EL4 whole cell lysate Lane 2: human fetal thymus lysate Lane 3: human spleen lysate Lane 4: HUT78 whole cell lysate Lane 5: Jurkat whole cell lysate Lane 6: MOLT-4 whole cell lysate Lysates/proteins at 20 ug per lane.
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Western Blot at 1:2000 dilution Lane 1: EL4 whole cell lysate Lane 2: human fetal thymus lysate Lane 3: human spleen lysate Lane 4: HUT78 whole cell lysate Lane 5: Jurkat whole cell lysate Lane 6: MOLT-4 whole cell lysate Lysates/proteins at 20 ug per lane.

Documents

Further Information

Additional Names:
T-cell immunoreceptor with Ig and ITIM domains, V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3, TIGIT, VSIG9, VSTM3
Application Note:
For WB starting dilution is: 1:2000
Background:
Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Background References:
  • Ota T.,et al.Nat. Genet. 36:40-45(2004).
  • Bechtel S.,et al.BMC Genomics 8:399-399(2007).
  • Yu X.,et al.Nat. Immunol. 10:48-57(2009).
  • Stengel K.F.,et al.Proc. Natl. Acad. Sci. U.S.A. 109:5399-5404(2012).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This TIGIT antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 12-142 amino acids from human TIGIT.
NCBI Gene ID #:
201633
NCBI Official Name:
T-cell immunoreceptor with Ig and ITIM domains
NCBI Official Symbol:
TIGIT
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
26 kDa
Protein Accession #:
Q495A1
Protein GI Number:
121943253
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Immunology
Swissprot #:
Q495A1
User NOte:
Optimal dilutions for each application to be determined by the researcher.