TargetMol

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea

Product Code:
 
TAR-T22424
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T22424-1mg1mg£57.00
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TAR-T22424-2mg2 mg£69.00
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TAR-T22424-5mg5mg£92.00
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TAR-T22424-1mL1 mL * 10 mM (in DMSO)£107.00
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TAR-T22424-10mg10mg£129.00
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TAR-T22424-25mg25mg£243.00
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TAR-T22424-50mg50mg£377.00
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TAR-T22424-100mg100mg£530.00
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TAR-T22424-200mg200mg£730.00
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This product comes from: Austria.
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Further Information

Bioactivity:
SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib. SC-1 potently inhibits the phosphorylation of STAT3 by blocking STAT3 phosphorylation and activation, and induces apoptosis in hepatocellular carcinoma cell lines[1].
CAS:
1313019-65-6
Formula:
C21H13ClF3N3O2
Molecular Weight:
431.8
Pathway:
Stem Cells; JAK/STAT signaling; Apoptosis
Purity:
0.9941
SMILES:
N#Cc(cc1)ccc1Oc(cc1)ccc1NC(Nc(cc1)cc(C(F)(F)F)c1Cl)=O
Target:
Apoptosis; STAT

Documents

References

1. Chun-Yu Liu, et al. Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT3 inactivation in human breast cancer cells. Breast Cancer Res. 2013;15(4):R63.