TargetMol

Dehydrocorydaline

Product Code:
 
TAR-T5S2358
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
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TAR-T5S2358-1mg1mg£91.00
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TAR-T5S2358-2mg2mg£108.00
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TAR-T5S2358-5mg5mg£138.00
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TAR-T5S2358-10mg10mg£177.00
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TAR-T5S2358-25mg25mg£265.00
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TAR-T5S2358-50mg50mg£359.00
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TAR-T5S2358-100mg100mg£506.00
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Further Information

Bioactivity:
1. Dehydrocorydaline exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSCLC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimerization of MyoD and E proteins, thus resulting in MyoD activation and myoblast differentiation. 3. Dehydrocorydaline shows antiplatelet effects, it inhibits thrombin-induced platelet aggregation in a low dose ( IC50= 34.914 ug/mL). 4. Dehydrocorydaline has anti-inflammatory and antinociceptive effects. 5. Dehydrocorydaline inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as well as cleaving PARP.
CAS:
30045-16-0
Formula:
C22H24NO4
Molecular Weight:
366.436
Pathway:
DNA Damage/DNA Repair; MAPK; Autophagy; Proteases/Proteasome; Microbiology/Virology; Apoptosis; Chromatin/Epigenetic
Purity:
0.9836
SMILES:
COc1ccc2c(C)c3-c4cc(OC)c(OC)cc4CC[n+]3cc2c1OC
Target:
BCL; PARP; p38 MAPK; Caspase; Parasite; Autophagy

Documents

References

Lee J , Sohn E J , Yoon S W , et al. Anti-Metastatic Effect of Dehydrocorydaline on H1299 Non-Small Cell Lung Carcinoma Cells via Inhibition of Matrix Metalloproteinases and B Cell Lymphoma 2[J]. Phytotherapy Research, 2017, 31(3):441-448.