AdipoGen Life Sciences

Leucettinib-21

Product Code:
 
AG-MR-C0047
Product Group:
 
Other Biochemicals
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
Short term: +4°C. Long term: -20°C
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Chemical Structure
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Chemical Structure

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This product comes from: Switzerland.
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Further Information

Appearance:
Pale yellow to off-white powder.
CAS:
2732859-75-3
Form:
solid
GHS Symbol:
GHS07
Handling Advice:
Keep cool and dry. Protect from light and moisture.
Hazards:
H319
Long Description:
Chemical. CAS: 2732859-75-3. Formula: C18H22N4O2S. MW: 358.5. Soluble in DMSO (10mM) or ethanol. Potent inhibitor of DYRK1A (IC50=2.4nM), DYRK1B (IC50=6.7nM), CLK1 (IC50=11.8nM) and CLK4 (IC50=5nM) kinases [2]. Inhibits the phosphorylation of Tau at Thr212 and cyclin D1 at Thr286, native DYRK1A in HT-22 cells and triggers cell apoptotic cell death. Corrects cognitive deficits in Ts65Dn model of Down syndrome and other models. iso-Leucettinib-21 (Prod. No. AG-MR-C0048) is a kinase-inactive isomer and should be used as a negative control together with this compound.
Molecular Formula:
C18H22N4O2S
Molecular Weight:
358.5
Package Type:
Vial
Precautions:
P280, P305, P351, P338
Product Description:
Potent inhibitor of DYRK1A (IC50=2.4nM), DYRK1B (IC50=6.7nM), CLK1 (IC50=11.8nM) and CLK4 (IC50=5nM) kinases [2]. Inhibits the phosphorylation of Tau at Thr212 and cyclin D1 at Thr286, native DYRK1A in HT-22 cells and triggers cell apoptotic cell death. Corrects cognitive deficits in Ts65Dn model of Down syndrome and other models. iso-Leucettinib-21 (Prod. No. AG-MR-C0048) is a kinase-inactive isomer and should be used as a negative control together with this compound.
Purity:
>99% (NMR)
Signal word:
Warning
Solubility Chemicals:
Soluble in DMSO (10mM) or ethanol.
Transportation:
Non-hazardous
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.

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