Chemodex

5(6)-Carboxy-2',7'-difluorofluorescein

Product Code:
 
CDX-C0262
Product Group:
 
Dyes, Stains, and Probes
Supplier:
 
Chemodex
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
Short term: +4°C. Long term: -20°C
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Chemical Structure
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Chemical Structure

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CDX-C0262-M05050 mg£104.00
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  • Further Information
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Further Information

Appearance:
Red powder.
CAS:
251450-64-3
Description:
5(6)-Carboxy-2',7'-difluorofluorescein is a fluorinated fluorescein used as a fluorescent dye used as a building block for synthesis of fluorescent probes. It is a replacement for the widely used carboxyfluorescein and fluorescein isothiocyanate since the absorption and emission are virtually unchanged. It can be excited with the 488nm spectral line of the argon-ion laser used in flow cytometers and confocal laser scanning microscopes. The lower pKa, increased resistance to photobleaching, high quantum yield, and diminished quenching on protein conjugation make the dyes superior to other fluoresceins for bioconjugation. Spectral data: Absoprtion 492nm, Emmision 516nm
EClass:
32160000
Form:
solid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C20H10F2O5.CH2O2/c21-13-5-11-17(7-15(13)23)27-18-8-16(24)14(22)6-12(18)19(11)9-3-1-2-4-10(9)20(25)26;2-1-3/h1-8,23H,(H,25,26);1H,(H,2,3)
InChiKey:
DDDAACFHCLQORF-UHFFFAOYSA-N
Molecular Formula:
C21H12F2O7
Molecular Weight:
414.32
Package Type:
Vial
Purity:
>95% (NMR)
SMILES:
OC(C(F)=C1)=CC2=C1C3(C(C=CC=C4)=C4C(O3)=O)C5=CC(F)=C(O)C=C5O2.CC(O)=O
Solubility Chemicals:
Soluble in DMSO.
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Number:
41105331
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

Documents

References

(1) W.-C. Sun, et al.; J. Org. Chem. 62, 6469 (1997) | (2) N.G. Norager, et al.; ACS Chem. Biol. 8, 2033 (2013)