Doxycycline hyclate
Product Code:
CDX-D0445
CDX-D0445
Regulatory Status:
RUO
RUO
Shipping:
Ambient
Ambient
Storage:
Short term: +20°C. Long term: +4°C
Short term: +20°C. Long term: +4°C
No additional charges, what you see is what you pay! *
| Code | Size | Price |
|---|
| CDX-D0445-G005 | 5 g | £64.00 |
Quantity:
| CDX-D0445-G010 | 10 g | £93.00 |
Quantity:
| CDX-D0445-G025 | 25 g | £174.00 |
Quantity:
Prices exclude any Taxes / VAT
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* Rare exceptions are clearly labelled (only 0.14% of items!).
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This product comes from: Switzerland.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
- Further Information
- Documents
- References
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Further Information
Appearance:
Yellow powder.
CAS:
24390-14-5
Description:
Doxycycline hyclate is a broad-spectrum tetracycline antibiotic. It binds to the 30S ribosomal subunit of bacteria and inhibits protein synthesis, preventing bacteria from growing and replicating. Next to its antibacterial activity it shows also anti-inflammatory, anti-protozoal, neuroprotective, anti-viral and anti-cancer properties. Doxycycline also inhibits selective human matrix metalloproteinases (MMP-8, MMP-9, MMP-13), inhibits replication of some viruses, inhibits the apicoplast of the malaria parasite Plasmodium spp. and reduces neuoinflammation. It can be used as a regulator for inducible gene expression systems where expression depends on either the presence (Tet-On) or absence (Tet-Off) of doxycycline. Intermediate for the synthesis of fluorescent probes.
EClass:
32160000
Form:
solid
GHS Symbol:
GHS07
Handling Advice:
Protect from light and moisture.
Hazards:
H302-H315-H319-H335
InChi:
InChI=1S/2C22H24N2O8/c2*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h2*4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31)/t7-,10+,14+,15-,17-,22-;/m0./s1
InChiKey:
HALQELOKLVRWRI-ZVACAFRPSA-N
MDL:
MFCD07357237
Molecular Formula:
C22H24N2O8 . HCl . 0.5H2O . 0.5C2H6O
Molecular Weight:
512.94
Package Type:
Vial
Precautions:
P261-P305+P351+P338
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
OC1=C2C([C@H](C)C3C(C2=O)=C(O)[C@@]4(O)C([C@H](N(C)C)C(O)=C(C(N)=O)C4=O)[C@H]3O)=CC=C1.CCO.OC5=C6C([C@H](C)C7C(C6=O)=C(O)[C@@]8(O)C([C@H](N(C)C)C(O)=C(C(N)=O)C8=O)[C@H]7O)=CC=C5.Cl.O.Cl
Solubility Chemicals:
Soluble in water (5mg/ml).
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
Documents
References
(1) G.M. Williamson; Chemotherapia 13, 1 (1968) | (2) I. Chopra; Antimicrob. Agents Chemother. 38, 637 (1994) | (3) G.N. Smith, et al.; Arthritis Rheum. 42, 1140 (1999) | (4) D.J. Gould, et al.; Gene Ther. 7, 2061 (2000) | (5) B.A. Cunha; Med. Clin. North Am. 90, 1089 (2006) | (6) B. Berman, et al.; Drugs Today 43, 27 (2007) | (7) J. Sagar, et al.; Anticancer Agents Med. Chem. 10, 556 (2010) | (8) M.O. Griffin, et al.; Pharmacol. Res. 63, 102 (2011) | (9) A.T. Das, et al.; Curr. Gene Ther. 16, 156 (2016) | (10) C. Balducci & G. Forloni; Front. Pharmacol. 10, 738 (2019) | (11) F. Chi, et al.; Virus Res. 345, 199388 (2024)