Florfenicol
Product Code:
CDX-F0069
CDX-F0069
Regulatory Status:
RUO
RUO
Shipping:
Ambient
Ambient
Storage:
Short term: +20°C. Long term: +4°C
Short term: +20°C. Long term: +4°C
No additional charges, what you see is what you pay! *
| Code | Size | Price |
|---|
| CDX-F0069-G005 | 5 g | £197.00 |
Quantity:
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This product comes from: Switzerland.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
Typical lead time: 7-10 working days.
Contact us for more accurate information.
- Further Information
- Documents
- References
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Further Information
Appearance:
White to off white crystalline.
CAS:
73231-34-2
Description:
Florfenicol is a broad-spectrum fluorinated antibiotic and a derivative of thiamphenicol and analog of chloramphenicol. Florfenicol inhibits bacterial protein synthesis by binding to the A site of the 23S rRNA in the 50S subunit of the 70S ribosome, blocking peptidyl transferase activity, and thereby preventing peptide bond formation, which makes it effective against various bacteria. It is primarily used in veterinary medicine to treat respiratory infections in cattle and swine, and to prevent Salmonella infection in poultry. Although florfenicol is primarily known for its antimicrobial activity, it also shows immunomodulatory properties, including anti-inflammatory activity, downregulating pro-inflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6, suppression of innate immune responses, affect lymphocyte proliferation and immunoglobulin production, and influence TLR expression in immune cells.
EClass:
32160000
Form:
solid
GHS Symbol:
GHS08, GHS09
Handling Advice:
Protect from light and moisture.
Hazards:
H361fd-H372-H410
InChi:
InChI=1S/C12H14Cl2FNO4S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-15)16-12(18)11(13)14/h2-5,9-11,17H,6H2,1H3,(H,16,18)/t9-,10-/m1/s1
InChiKey:
AYIRNRDRBQJXIF-NXEZZACHSA-N
MDL:
MFCD00864834
Molecular Formula:
C12H14Cl2FNO4S
Molecular Weight:
358.21
Package Type:
Vial
Precautions:
P202-P260-P264-P273-P280-P308+P313
Purity:
>98% (Assay)
Signal word:
Danger
SMILES:
[C@@H]([C@H](NC(C(Cl)Cl)=O)CF)(O)C1=CC=C(S(C)(=O)=O)C=C1
Solubility Chemicals:
Soluble in DMSO (30mg/ml), DMF (20mg/ml) or ethanol (10mg/ml).
Source / Host:
Synthetic
Transportation:
Excepted Quantity
UN Nummer:
UN3077
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.
Documents
References
(1) H.C. Neu & K.P. Fu; Antimicrob. Agents Chemother. 18, 311 (1980) | (2) V.P. Syriopoulou, et al.; Antimicrob. Agents Chemother. 19, 294 (1981) | (3) R. Graham, et al.; Eur. J. Clin. Microbiol. Infect. Dis. 7, 691 (1988) | (4) M. Cannon, et al.; J. Antimicrob. Chemother. 26, 307 (1990) | (5) Y. Ueda & I. Suenaga; J. Vet. Med. Sci. 57, 363 (1995) | (6) S. Priebe & S. Schwarz; Antimicrob. Agents Chemother. 47, 2703 (2003) | (7) G. Shuang, et al.; Immunol. Invest. 40, 356 (2011) | (8) X. Guo, et al.; Environ. Res. 244, 117934 (2024) (Review)